منابع مشابه
Vascular Smooth Muscle Calcium Channels
Voltage-gated Ca 21 channels of the plasma membrane open in response to changes in cell membrane potential, providing an important pathway for regulated entry of extracellular Ca ions. Ca channels comprise a family of structurally related proteins displaying tissueand stage-specific expression. They are classified as either high voltage-activated (HVA) or low voltage-activated (LVA) and can be ...
متن کاملEffects of pioglitazone on calcium channels in vascular smooth muscle.
Pioglitazone, an insulin-sensitizing, antidiabetic agent, has blood pressure-lowering effects in insulin-resistant hypertensive rats and attenuates growth factor-induced increases of intracellular Ca2+ in rat aortic vascular smooth muscle cells. To determine whether modulation of voltage-dependent Ca2+ channels plays a role in this association, we investigated the effects of pioglitazone on vol...
متن کاملCalcium and vascular smooth muscle contraction.
Radioactive calcium flux in rabbit aorta was studied to evaluate factors regulating the movement of calcium into and out of the cell. Calcium content was estimated both from (1) the amount of Ca present in the tissue and the specific activity of Ca in the bathing medium, and (2) determination of chemical calcium by atomic absorption spectrophotometry. Calcium efflux was followed by washing aort...
متن کاملCalcium Sparks Unleashed in Vascular Smooth Muscle
Hypertension is a progressive disease involving an increase in arterial constriction. It constitutes a major risk factor leading to stroke, heart disease, and kidney failure. Understanding the molecular pathways involved in arterial tone regulation is crucial to increasing our understanding of blood pressure regulation. Recently, a novel mechanism involving small-localized bursts of calcium ins...
متن کاملLow voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking.
An important path of extracellular calcium influx in vascular smooth muscle (VSM) cells is through voltage-activated Ca2+ channels of the plasma membrane. Both high (HVA)- and low (LVA)-voltage-activated Ca2+ currents are present in VSM cells, yet little is known about the relevance of the LVA T-type channels. In this report, we provide molecular evidence for T-type Ca2+ channels in rat arteria...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.89.7.560